Multisystem inflammatory syndrome in children (MIS-C) – Signs and symptoms

Fever (Source: Pixabay)

Multisystem inflammatory syndrome in children (MIS-C) is also known as Pediatric inflammatory multisystem syndrome.

This syndrome is characterized by hyperinflammatory shock that in-turn could be represented by extraordinary inflammation and critical illness. These conditions are mostly responsive to anti-inflammatory agents, such as intravenous immunoglobulin, and corticosteroids.

Signs and symptoms of MIS-C could be associated with different systems, as:

(1) Constitutional, including Fatigue, myalgia, and Fever,

(2) Gastrointestinal, including abdominal pain/diarrhea, and vomiting,

(3) Eyes and skin, including conjunctivitis, and cheilitis,

(4) Respiratory, including dyspnea and cough,

(5) Neurologic, including headache,

(6) Dermatologic, including rash.

Fever, abdominal pain/diarrhea, and vomiting are most commonly reported symptoms.

Summary in German language (Zusammenfassung in deutscher Sprache)

Das Multisystem-Entzündungssyndrom bei Kindern ist durch einen hyperinflammatorischen Schock gekennzeichnet. Einige der Anzeichen und Symptome dieses Syndroms sind Fieber, Bauchschmerzen / Durchfall, Erbrechen, Kopfschmerzen und Hautausschlag.


Ahmed, M., Advani, S., Moreira, A., Zoretic, S., Martinez, J., Chorath, K., Acosta, S., Naqvi, R., Burmeister-Morton, F., Burmeister, F., Tarriela, A., Petershack, M., Evans, M., Hoang, A., Rajasekaran, K., Ahuja, S., & Moreira, A. (2020). Multisystem inflammatory syndrome in children: A systematic review. EClinicalMedicine, 26, 100527.

Usman Zafar Paracha

Usman Zafar Paracha is a sort of entrepreneur. He is the author of "Color Atlas of Statistics", and the owner of an Android game "Faily Rocket."