Glycyrrhiza glabra and its interaction with cyclosporin and midazolam

Glycyrrhiza glabra, which is popularly referred to as liquorice root, contains triterpene saponins, glycyrrhizin, and glycyrrhetinic acid. These constituents are partially responsible for anti-inflammatory activity, antidiuretic activity, antiepileptic activity, antiallergic activity, antioxidant activity, and potentially hypotensive activity. Nevertheless, Glycyrrhiza glabra inhibits platelet aggregation and also exerts vasorelaxant effects on the body. In terms of Glycyrrhiza glabra interaction with the drugs, it may alter the bioavailability of cyclosporin and midazolam by affecting the cytochrome P450 3A4 (CYP3A4) enzyme activity.

Source: 

Shaikh, A. S., Thomas, A. B., & Chitlange, S. S. (2020, May). Herb-drug interaction studies of herbs used in treatment of cardiovascular disorders-A narrative review of preclinical and clinical studies. Phytother Res, 34(5), 1008-1026. https://doi.org/10.1002/ptr.6585