Study Estimates Rate of Survival Following Minimally Invasive Repair of Failed Bioprosthetic Aortic Valves

Bioprosthetic valve (Source: Point:

In an analysis of about 460 patients with failed bioprosthetic aortic valves who underwent transcatheter valve-in-valve implantation, overall survival at one year was 83 percent, with survival associated with surgical valve size and mechanism of failure, according to a study in the July 9 issue of JAMA.

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Surgical aortic valve replacements increasingly use bioprosthesis (composed of biological tissue) implants rather than mechanical valves. Owing to a considerable shift toward bioprosthesis implantation, it is expected that there will be an increase in the number of patients with degeneration of these types of valves. Treatment of patients with failed bioprostheses is a clinical challenge; although reoperation is considered the standard of care, these patients are frequently elderly and have other medical conditions, and repeat cardiac surgery can pose significant illness and risk of death. Transcatheter aortic valve-in-valve implantation is a less invasive approach, however a comprehensive evaluation of survival after the procedure has not previously been performed, according to background information in the article.

Danny Dvir, M.D., of St. Paul’s Hospital, Vancouver, Canada, and colleagues evaluated survival of 459 patients after transcatheter valve-in-valve implantation inside failed surgical bioprosthetic valves using a multinational registry. The patients (average age, 78 years) underwent implantation between 2007 and May 2013 at 55 centers.

Reasons for bioprosthesis failure were stenosis (narrowing of the valve opening; 39.4 percent), regurgitation (backflow of blood through the orifice of the valve due to imperfect closing; 30.3 percent), and combined stenosis and regurgitation (30.3 percent). The overall 1-year survival rate was 83.2 percent.

Patients in the stenosis group had worse 1-year survival (76.6 percent) in comparison with the regurgitation group (91.2 percent) and the combined group (83.9 percent). Similarly, patients with small valves (≤ 21 mm) had worse 1-year survival (74.8 percent) compared with larger valves.

“Thorough assessment of candidates for valve-in-valve implantation is a key step to obtain optimal results. The current analysis highlights the need for meticulous evaluation of bioprosthesis mechanism of failure before attempting a valve-in-valve procedure,” the authors write.


Danny Dvir MD, John G. Webb MD, Sabine Bleiziffer MD, Miralem Pasic MD, PhD, Ron Waksman MD, Susheel Kodali MD, Marco Barbanti MD, Azeem Latib MD, Ulrich Schaefer MD, Josep Rodés-Cabau MD, Hendrik Treede MD, Nicolo Piazza MD, PhD, David Hildick-Smith MD, Dominique Himbert MD, Thomas Walther MD, Christian Hengstenberg MD, Henrik Nissen MD, PhD, Raffi Bekeredjian MD, Patrizia Presbitero MD, Enrico Ferrari MD, Amit Segev MD, Arend de Weger MD, Stephan Windecker MD, Neil E. Moat FRCS, Massimo Napodano MD, Manuel Wilbring MD, Alfredo G. Cerillo MD, Stephen Brecker MD, Didier Tchetche MD, Thierry Lefèvre MD, Federico De Marco MD, Claudia Fiorina MD, Anna Sonia Petronio MD, Rui C. Teles MD, Luca Testa MD, Jean-Claude Laborde MD, Martin B. Leon MD, Ran Kornowski MD. Transcatheter Aortic Valve Implantation in Failed Bioprosthetic Surgical Valves. JAMA. 2014; 312(2):162-170. doi:10.1001/jama.2014.7246

Editor’s Note:

Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

Media Advisory:

To contact Danny Dvir, M.D., call Dave Lefebvre at 604-682-2344, ext. 66987; or email

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