As a result of hypoglycemia, sympathoadrenal responses – involving the sympathetic nervous system and the adrenal glands especially sympathetic activity including the secretion of epinephrine and norepinephrine – are attenuated but the mechanism behind the alteration of responses as a result of hypoglycemia needs further research. It is suggested that the changes must have been taking place within the central nervous system (CNS) or some related connections.
To study the altered mechanism of sympathoadrenal responses as a result of hypoglycemia, we may start by researching on the optimal noninvasive methods of studying the human brain function. Moreover, the mechanism behind hypoglycemia-associated autonomic failure (HAAF) and the proper differentiation of diabetic patients with HAAF from those diabetic patients without HAAF could also help in identifying the mechanism of altered responses.
“Hypotheses regarding CNS-mediated mechanisms of the attenuated sympathoadrenal responses to hypoglycemia that cause HAAF include the systemic-mediator hypothesis, the brain fuel–transport hypothesis, the brain-metabolism hypothesis, and the cerebral-network hypothesis,” Researchers wrote in the paper.
You could work on these hypotheses and can come out with the better outcomes after proper research.
Philip E. Cryer, M.D. (2013). Mechanisms of Hypoglycemia-Associated Autonomic Failure in Diabetes N Engl J Med DOI: 10.1056/NEJMra1215228