Immune-based therapy and HIV research

Immune based HIV therapy related research ideas

In the context of immune-based therapy, many of the genes and immune functions have been found to be related to the control of HIV. These include “Δ32 allele of CCR5, HLA-B5701, and HLA-B27 alleles, the NK inhibitory receptors KIR3DS1 and KIR3DL1; increased expression of proteins necessary for granule exocytosis-mediated cytotoxicity, such as granzyme A, granzyme B, and perforin; and higher numbers of both plasmacytoid dendritic cells and polyfunctional T cells in elite controllers compared with non-controllers or cART-suppressed patients” but the optimal association of any of these to control HIV needs further research.

Favorable changes have been found in SIV-infected macaques after IL-21 administration, i.e. elevated perforin and granzyme B expression in CD8, effector CD4, and NK cell subsets. However, whether the effect of these conditions is positive on antiviral therapy and elimination of latently infected cells or not needs further research.

Auranofin is a gold based compound used for the treatment of rheumatoid arthritis. Mechanism of action of this compound is not completely known.

Reference:

Badley AD, Sainski A, Wightman F, & Lewin SR (2013). Altering cell death pathways as an approach to cure HIV infection. Cell death & disease, 4 PMID: 23846220

Usman Zafar Paracha

Usman Zafar Paracha is a sort of entrepreneur. He is the author of "Color Atlas of Statistics", and the owner of an Android game "Faily Rocket."

%d bloggers like this: