Some research ideas related to Prostate cancer and cadmium carcinogenesis

Cancer Research

Prostate cancer is among the major cause of morbidity and mortality in humans and accounts for 11% of total deaths caused by cancer in men. It is the second leading cause of cancer related deaths in American men.

[hana-code-insert name=’StumbleUpon’ /][hana-code-insert name=’Reddit’ /] The pathways and mechanisms related to prostate cancer growth is not clear. Much of the work can be done in this regard. Researchers have reported that “we are still far from clearly defining the complex etiology of this disease, which probably includes genetic background, age and physiologic status, lifestyle (e.g. diet and tobacco smoking) and exposure to other environmental risk factors.”

Researchers are of the opinion that prostate is the main site for cadmium carcinogenesis but the mechanism is still not known. It has been suggested that cadmium is carcinogenic in multiple ways such as “oxidative stress, proto-oncogene activation, altered DNA methylation and dysregulated gene expression”.

Reference:

Pierpaolo Aimola, Marco Carmignani, Anna Rita Volpe, Altomare Di Benedetto, Luigi Claudio, Michael P. Waalke, Adrie van Bokhoven, Erik J. Tokar, Pier Paolo Claudio, (2012). Cadmium Induces p53-Dependent Apoptosis in Human Prostate Epithelial Cells. PLoS ONE, doi:10.1371/journal.pone.0033647

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