Mechanism for Early Pregnancy Loss has been found; Research

Early pregnancy lossResearchers have found the mechanism behind the early pregnancy loss (EPL).

This research has been done by researchers from Zhejiang University in China and published online in the journal of BMC Medicine.

It has been reported that almost 75% of women have one or more EPL causing loss of unrecognized or histologically known pregnancies. On the other hand, the incidence of recognized EPL is almost 10-15%.

Researchers worked on Villous and decidual tissues of patients with EPL and “women undergoing selective pregnancy termination in the first-trimester (gestational age,seven to nine weeks) for nonmedical reasons in Women’s Hospital, School of Medicine, Zhejiang University, between September 2006 and May 2007.” They diagnose EPL with vaginal bleeding and/or lower abdominal pain along with the findings of pelvic and ultrasonic examination. They also selected mice models for study.

[hana-code-insert name=’StumbleUpon’ /][hana-code-insert name=’Reddit’ /] Researchers have found that embryonic defects in DNA methylation, due to DNA methyltransferases, are the cause of EPL. They have found the erratic DNA methylation lead to disrupted embryonic implantation, increased fetal absorption, and poor fetal and placental development.

According to researchers, it is the first of its kind of study to find the DNA maintenance methylation in the pathogenesis of EPL. This research showed that maternal defects are not the cause of EPL.

Researchers are of the opinion that “further experiments are needed to clarify changes in gene expression and methylation states of genes under the DNA methylation maintenance defect in EPL pathogenesis.”


Li-Jun Yin, Yu Zhang, Ping-Ping Lv, Wei-Hua He, Yan-Ting Wu, Ai-Xia Liu, Guo-Lian Ding, Fan Qu, Chen-Ming Xu, Min-Yue Dong, Xiao-Ming Zhu and He-Feng Huang, (2012). Insufficient maintenance DNA methylation is associated with abnormal embryonic development. BMC Medicine, doi:10.1186/1741-7015-10-26

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