A protein namely surfactant protein-D (SP-D) is found to be a strong predictor of Cardiovascular disease (CVD). This protein is synthesized in Lungs.
According to a study published in “European Heart Journal”, circulating SP-D is found to be associated with CVD and angiographically diagnosed coronary artery disease independent of certain other established risk factors such as cholesterol, smoking and age.
Actually SP-D acts as a body’s defensive mechanism by protecting it from micro-organisms and antigens that are inhaled everyday. This protein gets bind to the surface of the antigen or micro-organism and promote its removal from the body. Protein’s level in the body is increased in the case of inflammation or reduced working of the lungs for example when someone catches a flu or cold or some other respiratory tract infection. When lung function is impaired SP-D leaks from the body, goto the blood and increases the risk of atherosclerosis. (Atherosclerosis is a disease of the arteries in which there are raised areas of degeneration or cholesterol deposits on the inner surfaces of the arteries.)
This protein is found to be a helpful biomarker in linking the lung inflammation or injury to CVD.
Reference and further reading:
Hill, J. et al. (2011). Circulating surfactant protein-D and the risk of cardiovascular morbidity and mortality. European Heart Journal. June 8, 2011.