Researchers have found that losing the hope of a good night’s sleep is one of the major factors in suicidal tendencies.
This research has been published online in the Journal of Clinical Sleep Medicine.
Previously known risk factors related to suicides were insomnia – difficulty in sleeping – and nightmares. However, the process through which these factors were related to suicide was largely unknown. This new study confirms those factors, and shows the relation of those factors with suicide while adding another element of hopelessness about sleep, which is different from other types of hopelessness such as those related to personal relationships and careers, according to Dr. W. Vaughn McCall, Chair of the Medical College of Georgia Department of Psychiatry and Health Behavior at Georgia Regents University and corresponding author of the study. Read more…
Researchers have found the probable mechanism through which the glutamate is more active in the brains of the people who try to suicide.
This research has been published online in the journal Neuropsychopharmacology.
Glutamate is an amino acid involved in signaling between the nerve cells and has been found to be involved in depression.
“The findings are important because they show a mechanism of disease in patients,” Brundin, associate professor of translational science and molecular medicine in MSU’s College of Human Medicine, said in a statement. “There’s been a lot of focus on another neurotransmitter called serotonin for about 40 years now. The conclusion from our paper is that we need to turn some of that focus to glutamate.”
Researchers in this study worked on the spinal fluid of 100 patients in Sweden. They checked the glutamate activity by determining the quinolinic acid that is involved in chemical switch causing glutamate to send more signals to neighboring cells. In the patients, about 67% of the participants were admitted after attempting suicide while the rest were healthy.
Researchers found two times more quinolinic acid in the spinal fluid of the suicide attempters as compared to the healthy people showing elevated glutamate signaling between the nerve cells. Moreover, the highest levels of acid were found in the people with strongest desire to kill themselves. The patients also showed decreased levels of quinolinic acid in the patients after six months, when the suicidal behavior stopped. Read more…