Scientists have reported the promising results of panobinostat along with cisplatin against mesothelioma tumor cells.
Genetics and Molecular Research
Panobinostat is an experimental drug developed by Novartis – a pharmaceutical company. Although, it is still in its early stages of testing but has shown promising results in combination with cisplatin against mesothelioma.
“Cisplatin and panobinostat exposure of the cells for 24 h resulted in decreased cell survival. The combined treatment was found to be more effective,” Scientists noted.
This drug works by inhibiting the production of enzymes that enable mesothelioma cancer cells to grow at the molecular level. This process inhibits the spread of cancer cells.
After testing the combination against mesothelioma, scientists have found that mesothelioma cells were unable to survive in the laboratory setting but the healthy cells were mostly unaffected.
The same combination has also been tested successfully for other cancers such as multiple myeloma and lymphoma.
Although the results were impressive but these are initial results and scientists are planning to enter into a next phase of research, i.e. research on animals.
Gultekin KE et al. (2013). Effects of cisplatin and panobinostat on human mesothelial (Met-5A) and malignant pleural mesothelioma (MSTO-211H) cells. Genetics and Molecular Research DOI: 10.4238/2013.November.11.2
Malignant pleural mesothelioma (MPM) is a rare but aggressive form of abnormal growth of cells/tissues from the mesothelial surfaces of the pleura. This is a form of cancer with poor prognosis and is a therapeutic challenge for researchers as it always recurs locally.
Surgery such as pleurectomy/decortication (P/D) or extrapleural pneumonectomy (EPP) is a well accepted form of therapeutic strategy for MPM.
Radiotherapy is also widely used to treat MPM but this needs more research. Moreover, postoperative radiation therapy is also a matter of further research. Research is also required on the thinking that radiation therapy is palliative therapy for MPM. Further research is also needed on the role of prophylactic radiation therapy as interventionist treatment.
Pemetrexed is an anticancer drug primarily used for the treatment of pleural mesothelioma and non-small cell lung cancer. It is a multi-targeted antifolate compound i.e. it inhibits many of the key enzymes (thymidylate synthase (TS) and dihydrofolate reductase (DHFR), glycinamide ribonucleotide formyl transferase (GARFT) and aminoimidazole carboxamide formyl transferase) involved in folic acid metabolism. Continue reading Pemetrexed related cancer research suggestions→
Mesothelioma is a rare form of aggressive cancer that affects the membrane lining of the lungs and abdomen. It is usually caused by exposure to asbestos.
It is usually the cancer of old age due to its long latency period. The average age at the time of diagnosis has been found to be sixty-five years.
Although, it is extremely rare in children but certain studies showed the presence of mesothelioma in children. Only nine cases of the childhood mesothelioma (pediatric mesothelioma) were found in U.S. between 1999 and 2002. Seven cases of malignant mesothelioma were reported in Memorial Hospital from 1953 to 2006. Among those cases, five patients died within two years of the diagnosis while the two patients lived more than five years.
A research published in 1980, studied eighty children in which ten children had mesothelioma cancer. Researchers found that only four had been thought to be exposed to asbestos. Six of them were boys. Pleural mesothelioma was diagnosed in eight children. Two children lived until the age of nineteen. Continue reading Childhood Mesothelioma→
Researchers have recently published a case report of 61 years old Japanese, who is a “disease-free survivor of malignant pleural mesothelioma” for seven years utilizing only heat therapy and chemotherapy.
This case report has been published online in the Journal of Medical Case Reports.
This Japanese man, with five years of asbestos exposure, went to hospital for chest pain. His scan showed thickening on the right lining around the lungs and some small nodules. Moreover, a tumor growing on the muscles of the chest wall was also found. This tumor was later found to be the sarcomatoid type of malignant pleural mesothelioma, which is the most aggressive mesothelioma cell type.
When the clinicians chose some therapeutic strategies for the patient, he refused to take the invasive therapy such as surgery. So, the doctors chose to treat him with heat therapy and chemotherapy with the drugs cisplatin and irinotecan. Heat therapy, also known as hyperthermia, helps in cancer treatment by exposing the body tissues to the temperatures of up to 113°F. Continue reading Heat along with Chemotherapy could help to treat mesothelioma→