Posts Tagged ‘blood’

New test detects toxic prions in blood

Prion Protein Fibrils (Credit: Flickr, NIAID, CC BY)Main Points:

The first cases of Mad Cow disease in humans (properly called variant Creutzfeld Jakob Disease, or vCJD) occurred in the late 1990s and are thought to be the consequence of eating contaminated beef products. Since then, several cases of secondary infections caused by transfusions with blood from donors who subsequently developed vCJD have been reported, raising concerns about the safety of blood and blood products. A paper published in PLOS Pathogens on June 12th now describes an assay that can detect prions in blood samples from humans with vCJD and in animals at early stages of the (asymptomatic) incubation phase. Read more…

Be the first to comment - What do you think?  Posted by saypeople - June 13, 2014 at 2:00 am

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Study Examines Effect of Intervention to Increase Blood Flow During and After Major Surgery

Kidney surgery (Credit: Flickr/NDNG)Main Points:

In a study that included high-risk patients undergoing major gastrointestinal surgery, the use of a cardiac-output guided intervention to improve hemodynamics (blood flow and blood pressure) during and after surgery did not reduce complications and the risk of death after 30 days, compared with usual care. However, when the current results were included in an updated meta-analysis, the intervention was associated with a clinically important reduction in complication rates, according to a study published by JAMA. The study is being released early online to coincide with its presentation at the American Thoracic Society International Conference. Read more…

Be the first to comment - What do you think?  Posted by saypeople - May 20, 2014 at 2:00 am

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Novel blood test may help predict impending preterm birth

Fetus (Credit: lunar caustic/Flickr)Main Point:

Blood-based diagnostic test can distinguish between true and false labor.

Published in:

PLOS ONE

Study Further:

A blood-based diagnostic test accurately predicted whether 70% of female study participants with threatened preterm labor (TPTL) would or would not give birth prematurely. Results were published May 14, 2014, in the open access journal PLOS ONE, by Dr Jan Heng and Professor Stephen Lye from the Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada.

“A lot of TPTL women are unnecessarily hospitalized,” says Professor Stephen Lye. “We want to develop a test that can differentiate between true and false labor so that women in true labor can receive the appropriate medical care while women in false labor will receive supportive care and be discharged.” Preterm birth worldwide remains the main cause of childbirth-related mortality in the developed world. Only 5% of the women hospitalized with signs of premature labor (i.e. TPTL) will deliver a premature baby within ten days. Read more…

Be the first to comment - What do you think?  Posted by saypeople - May 15, 2014 at 2:00 am

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Study Estimates Proportion of Adults Affected by New Blood Pressure Guideline

Main Points:

Applying the updated 2014 blood pressure (BP) guideline to the U.S. population suggests that nearly 6 million adults are no longer classified as needing hypertension medication, and that an estimated 13.5 million adults would now be considered as having achieved goal blood pressure, primarily older adults, according to a JAMA study released online to coincide with the 2014 American College of Cardiology Scientific Sessions.

Published in:

JAMA

Study Further:

Ann Marie Navar-Boggan, M.D., Ph.D., of Duke University Medical Center, Durham, N.C., and colleagues quantified the proportion of adults potentially affected by the updated 2014 recommendations, compared to the previous guideline, issued nearly 10 years ago (Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure [JNC 7]). The researchers used data from the National Health and Nutrition Examination Survey (NHANES) between 2005 and 2010 (n = 16,372), and evaluated hypertension control and treatment recommendations for U.S. adults. The new guideline proposed less restrictive BP targets for adults 60 years of age or older and for those with diabetes and chronic kidney disease.

Read more…

Be the first to comment - What do you think?  Posted by saypeople - March 29, 2014 at 11:00 pm

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Using Age to Distinguish Normal From Abnormal Blood Test Results Appears to Safely Exclude Lung Blood Clots in Older Patients

Main Points:

Chicago – Using a patient’s age to raise the threshold for an abnormal result of a blood test used to assess patients with a suspected pulmonary embolism (blood clot in lungs) appeared to be safe and led to fewer healthy patients with the diagnosis, according to a study in the March 19 issue of JAMA.

Published in:

JAMA

Study Further:

D-dimer is a breakdown product of a blood clot, and measuring D-dimer levels is one way doctors exclude a diagnosis of pulmonary embolism (PE). Several studies have shown that D-dimer levels increase with age. As a result, the proportion of healthy patients with abnormal test results (above 500 µg/L for most available commercial tests) increases with age, limiting the test’s clinical usefulness in older people, according to background information in the article.

Read more…

Be the first to comment - What do you think?  Posted by saypeople - March 19, 2014 at 1:00 am

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