Researchers have found that blood of youngsters can rejuvenate the heart of the old ones – at least in mice.
Previously, researchers found that the blood from the young mice could rejuvenate the brain of the older mice. (Nature, doi:10.1038/nature10357).
In the new study, researchers worked on two mice; one was 2-month-old and the other was 23-month-old having cardiac hypertrophy – a condition in which the heart muscle thickens leading to heart failure. Researchers surgically joined the circulatory system of the two mice that caused the blood to flow around each other’s bodies.
Researchers found that the heart of the older mouse reverted back to almost the same size as that of the younger animal and the heart of the younger animal remained unaffected even after circulating the blood from the older mice. Read more…
This research has been published online in the Journal of the American Medical Association.
Researchers, in this study, worked on a corn-based hydroxyethyl starch solution, a commonly used blood volume expander, and compared it with other products. Researchers worked on 38 clinical trials involving 10,880 patients around the world and found that the chances of kidney failure and mortality were more in the patients, who received hydroxyethyl starch solutions.
“It’s used around the world in emergency rooms, intensive care units and surgical suites,” Zarychanski said in a short video produced by the university.
“Physicians like myself have often suspected the product may be associated with harm, but no study was adequately … designed to test this hypothesis.”
“We looked at all the studies conducted throughout the world to date on this product and we found clear evidence that in patients who received this product, compared to patients who received other resuscitation fluids, those patients have a greater chance of dying and having acute renal failure,” he added. Read more…
Diagnostic tool to determine down to 20 nm of individual particles in blood sample at an early stage
Researchers from Norway have developed the sensor that is capable of determining the individual particles in the blood sample and can help to detect cancer such as prostate and ovarian cancer in very early stages.
It is the world’s first sensor with such capability of determination developed by researchers from SINTEF, the largest independent research organization in Scandinavia, in collaboration with the researchers from Stanford University in the USA and the University of Oslo (UiO). This nano-particle sensor has been developed in MiNaLab in Oslo.
Soluble mesothelin-related peptide could be used as a biomarker for asbestos related disorders; Research
Researchers have found that serum soluble mesothelin-related peptide (SMRP) could be used for the detection of the severity of diseases associated with asbestos.
This research has been published online in the journal of Safety and Health at Work.
Asbestos is a carcinogenic substance. One of the most fatal diseases associated with asbestos is malignant mesothelioma, which is the cancer of the lungs. Among the other diseases from this material are pleural plaques, asbestosis, and diffuse pleural thickening. Serum SMRP is the blood based biomarker. In some of the studies, it has been reported that the increased levels of serum SMRP level is associated with the duration of past asbestos exposure.
Researchers have worked on 514 subjects, which were exposed to asbestos. They were then assessed for the severity of the diseases associated with asbestos while comparing the SMRP levels with the severity of the disease. They found that SMRP is related to the disablement from non-malignant diseases associated with asbestos, so this can be used in the diagnosis of severity from asbestos related disorders. Read more…
Researchers have found 68 regions of genome that affects the size and number of platelets, which are responsible for clotting of the blood and healing of wounds. An increase in the number of platelets causes thrombotic events such as strokes and heart attacks while a decrease in the number of platelets results in abnormal bleeding.
This research has been performed by an international team of researchers and published online in the November 30 issue of the Journal Nature.
In this study, researchers worked on genome wide meta-analysis of almost 68,000 individuals and have combined different advanced techniques and used a series of biological analyses to identify the new genetic variants involved in the formation of the platelets. In the research process, researchers firstly identify the genes involved in the formation of platelets through biological observations of these genes leading to the construction of protein-protein interaction network, showing how they interact, and near the end of the research they found the role of the genes in model organisms i.e. fruit fly and zebra fish.
Researchers found that decreasing the activity of one of these genes i.e. ARHGEF2 in fish, abolishes the production of platelets and red blood cells as the ability of blood forming cells to capture iron abolishes. Read more…