Outcomes of drug-drug interaction

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The outcomes of drug-drug interaction can be in different forms, including three most common forms. These are (1) Intensification or potentiation of effects, (2) Reduction of effects, and (3) Production of a unique response.

The intensification or potentiation of effects could also be referred to as Potentiative interaction. It can be in two sub-forms, (a) Increase in therapeutic effects as, for example, interaction between ampicillin and sulbactam could intensify and prolong therapeutic effects of ampicillin, and (b) Increase in adverse effects as, for example, interaction between aspirin and warfarin could significantly increase the risk of bleeding.

The reduction of effects could also be referred to as inhibitory interaction. It can be in two sub-forms, (a) Decrease in therapeutic effects as, for example, interaction between propranolol and albuterol could reduce therapeutic effects of albuterol, and (b) Decrease in adverse effects as, for example, interaction between naloxone and morphine could reduce toxicity symptoms of morphine.

The production of a unique response could be shown by an example of interaction between alcohol and disulfiram leading to unpleasant and dangerous responses.

Zusammenfassung in deutscher Sprache (Summary in German language)

Die Ergebnisse der Arzneimittel-Arzneimittel-Wechselwirkung können in verschiedenen Formen vorliegen, einschließlich (1) Intensivierung oder Potenzierung der Wirkungen, (2) Verringerung der Wirkungen und (3) Erzeugung einer einzigartigen Reaktion.

Source:

Burchum, J., Rosenthal, L., & Yeager, J. J. (2018). Study Guide for Lehne’s Pharmacology for Nursing Care *- eBook. Elsevier Health Sciences.

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