Complex congenital heart disease operations in babies increased after Fukushima nuclear power plant accident

Operation (Image source: Pixabay)
Operation (Image source: Pixabay)

Study Highlights:

  • In the years following the Fukushima nuclear accident, complex congenital heart disease operations increased in babies born in Japan.
  • While levels of radiation in the air have been declining, the number of operations for complex congenital heart disease remains high.

Operations for complex congenital heart disease in infants increased significantly in the four years following the 2011 Great East Japan Earthquake and nuclear accident in Fukushima, Japan, according to new research in the Journal of the American Heart Associationthe Open Access Journal of the American Heart Association/American Stroke Association.

This study does not show a direct cause and effect between children born in Japan in the years following the nuclear accident and incidence of complex congenital heart disease.

“Although this research focuses on events that occurred in Japan, the potential for nuclear accidents throughout the world is a global health concern,” said Kaori Murase, Ph.D., associate professor at Nagoya City University in Japan. “Our study suggests that a nuclear accident might increase the risk for complex congenital heart disease.”

Complex congenital heart disease occurs in the early stages of fetal development resulting in complicated and severe symptoms that require advanced surgery. In many cases, these abnormalities can affect health over the course of the patient’s lifetime. After the Chernobyl nuclear accident in 1986, congenital heart disease in neighboring countries increased.

While there has been no nationwide study of the effects of radiation on the Japanese population, the researchers focused on the incidence of complex congenital heart disease in children born after the nuclear accident. The researchers analyzed data on complex congenital heart disease operations in children from birth to 17 years of age between 2007 and 2014 collected by the Japanese Association for Thoracic Surgery.

In the four years following the Fukushima nuclear accidents, they found:

  • The number of operations for complex congenital heart disease in infants all over Japan increased 14.2 percent, whereas those performed on 1- to 17-year-old patients showed no significant change during the study period.
  • The complex congenital heart diseases that showed significant increases were those known to occur during various developmental stages of the heart.
  • The results suggest that damage occurred at various points in the early stages of heart development and not from damage to a single gene at a specific point in time.

Nuclear accidents may have wide-ranging adverse effects on various types of congenital heart disease. The earlier the radiation exposure happens in a developing heart, the more likely it is that the nuclear accident could have a negative impact on more parts of the heart,” Murase said.

Researchers also note that, while the concentration of radiation in the air in Japan was declining in 2014, the number of operations for complex congenital heart diseases remained high.

Stress to pregnant women, such as job loss, divorce, marital separation, or death of a loved one, is a known risk factor for some complex congenital heart disease. Since such stress likely occurred during the nuclear accident, researchers suggest that it may have played an indirect role in the increase of complex congenital heart disease.

“A nuclear accident is a problem that directly affects the lives of each of us,” she said. “More research is needed so that health effects from these types of accidents are not minimized.”

Co-authors are Joe Murase, B.S. and Akira Mishima, M.D., Ph.D. Author disclosures are on the manuscript.

The Japan Society for the Promotion of Science and Nagoya City University funded the study.


Statements and conclusions of study authors published in American Heart Association scientific journals are solely those of the study authors and do not necessarily reflect the association’s policy or position. The association makes no representation or guarantee as to their accuracy or reliability. The association receives funding primarily from individuals; foundations and corporations (including pharmaceutical, device manufacturers and other companies) also make donations and fund specific association programs and events. The association has strict policies to prevent these relationships from influencing the science content. Revenues from pharmaceutical and device corporations and health insurance providers are available at

About the American Heart Association

The American Heart Association is a leading force for a world of longer, healthier lives. With nearly a century of lifesaving work, the Dallas-based association is dedicated to ensuring equitable health for all. We are a trustworthy source empowering people to improve their heart health, brain health and well-being. We collaborate with numerous organizations and millions of volunteers to fund innovative research, advocate for stronger public health policies, and share lifesaving resources and information. Connect with us on, FacebookTwitter or by calling 1-800-AHA-USA1.

For Media Inquiries and AHA/ASA Expert Perspective: 214-706-1173

Karen Astle 214-706-1392;

For Public Inquiries: 1-800-AHA-USA1 (242-8721) and

Usman Zafar Paracha

Usman Zafar Paracha is a sort of entrepreneur. He is the author of "Color Atlas of Statistics", and the owner of an Android game "Faily Rocket."

Leave a Reply

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.