In a recent study, scientists have found that basal-like subtype of breast cancer is “a unique molecular entity” among 6 human cancer types (breast, ovarian, brain, colorectal, lung adenocarcinoma and squamous cell lung cancer). However, it shows similarity to squamous cell lung cancers.
[sociallocker]Scientists have also found that about 70% of Basal-like tumors are almost similar to squamous cell lung cancers than Luminal A and B breast tumors. These cancers are worthy of research as they have poor prognosis and have high chances of spreading in the body. Although, these diseases show high sensitivity to platinum-based therapies but the problem of resistance emerges rapidly.
This research shows that we have to consider the classification of tumors, i.e. tumors of one origin could show similarity to the tumors of the other origin. You can work on the classification of cancers.
Changes at the DNA level in the case of these cancers need further research. Scientists have also noted that it would be favorable, if we work on treatment strategy including “common molecular alterations of the tumor and/or the microenvironment” rather than the tumor’s tissue of origin.
You can work on Small interfering RNA (siRNA)-based therapeutics strategy against these cancers. Moreover, you can find whether these cancers show similar results with this therapeutic strategy further confirming the present research. You can also work on the mutational biomarkers of these cancers using DNA from formalin-fixed and paraffin-embedded (FFPE) tissues. You can join this method of detection with “Selection of Significant Expression-Correlation Differential Motifs” (SSECDM) to detect these cancers.
You can refer to The Cancer Genome Atlas (TCGA) project for cancer research.
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Aleix Prat et al. (2013). Genomic Analyses across Six Cancer Types Identify Basal-like Breast Cancer as a Unique Molecular Entity Scientific Reports DOI: 10.1038/srep03544