hnRNP-K homology (KH) domains are present in the C-terminal region of the proteins of IGF2BP family members and RNA-recognition motifs (RRMs) are in their N-terminal part. IGF2BP are insulin-like growth factor-2 mRNA-binding proteins that have the ability of RNA-binding and are oncofetal in nature.
There are indications that KH1/2 domains are important in the stabilization of IGF2BP-RNA complexes but it needs clear practical results. Moreover, structural analyses of different KH-domains (1-4) in complex with target RNAs could help in the development of novel compounds.
“Further research is certainly required to elucidate further if IGF2BPs serve roles in the process of wound healing, and whether this role is exploited in tumors for growth and metastasis and may lead to the mechanisms of IGF2BP1/3 re-expression in adult tissues,” Researchers wrote.
The current models in the study of IGF2BP need to be improved but according to the researchers transgenic mice (especially IGF2BP1 and 3) that replicate the re-expression found in cancer could be of great help in studying the mechanisms in-vivo and anti-IGF2BP drug development.
The mechanism through which the overexpression of the chicken ortholog of the human IGF2BP1, termed ZBP1 (Zipcode binding protein), slows down T47D cell migration is still not clear.
Bell JL, Wächter K, Mühleck B, Pazaitis N, Köhn M, Lederer M, & Hüttelmaier S (2013). Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression? Cellular and molecular life sciences : CMLS, 70 (15), 2657-75 PMID: 23069990