Researchers have found that not only quantity of food but the timing to take food is also important in controlling obesity.
This research has been published online in the journal Nature Medicine.
Researchers in this study worked on mice model. They removed the clock gene Arntl (also known as Bmal1) in the fat cells of the mice and found that the mice became obese as the removal of this gene caused the disturbance in the normal eating schedule of the mice. Remember, fat cells store excess energy and tell our brain about such energy levels. Previously researchers found that mutation in Clock, another important part of body-clock, also plays an important role in controlling obesity and energy balance.
Those genes drive suppression or expression signals of appetite in the hypothalamus in the daily food intake procedure. Upon disruption of these clocks in the fat cells, hypothalamic rhythm disturbed resulting in food craving at any time in 24 hours without any schedule. This disturbance in daily rhythm disturb metabolism also making obesity more prevalent.
Researchers have also worked on normal mice and found an increase in weight in normal mice by training them to copy the same eating pattern as those of the mice with removed time piece.
This study showed two interesting things. “The first is that a relatively modest shift in food consumption into what is normally the rest period for mice can favor energy storage,” Georgios Paschos PhD, a research associate in the lab of Garret FitzGerald, MD,FRS director of the Institute for Translational Medicine and Therapeutics , Perelman School of Medicine ,University of Pennsylvania, said in a statement. “Our mice became obese without consuming more calories.”
Arntl along with the Clock gene are also found to play an important role in the glucose homeostasis and metabolism.
So, remember that disturbing your eating schedule often could result in bad effects on your health. According to Penn Medicine News Release, people with night shifting have more chances of getting metabolic syndrome and obesity. Similarly, patients of sleep disorders have more chances of becoming obese.
Georgios K Paschos, Salam Ibrahim, Wen-Liang Song, Takeshige Kunieda, Gregory Grant, Teresa M Reyes, Christopher A Bradfield, Cheryl H Vaughan, Michael Eiden, Mojgan Masoodi, Julian L Griffin, Fenfen Wang, John A Lawson & Garret A FitzGerald, (2012). Obesity in mice with adipocyte-specific deletion of clock component Arntl. Nature Medicine, doi:10.1038/nm.2979