Shrinkable nanoparticles could be used to target tumors; Research

Shrinking nanoparticlesScientists have developed shrinkable nanoparticles that can be used to target tumors in the body.

This research has been done by the scientists from MIT and Harvard University, and has been published online in the March 5 issue of the Journal of the American Chemical Society.

Scientists have developed such nanotparticles that reduces to less than a third of the original size upon exposure to UV rays while the darkness or visible light open the nanoparticles back to their original sizes. According to scientists, this research could help in the delivery of cancer killing drugs directly to the tumors, which usually block all the particles except smallest particles of the size of 100 nanometers.

[hana-code-insert name=’StumbleUpon’ /][hana-code-insert name=’Reddit’ /]Scientists are of the opinion that these nanoparticles could be sent to the target cells while keeping them at the lowered size of about 40 nanometers under UV light and upon reaching the targets the UV light will be closed and the nanoparticles will be opened up to 150 nanometers size and release the drug.

You can read the abstract of the paper below;

We report a novel nanoparticulate drug delivery system that undergoes reversible volume change from 150 to 40 nm upon phototriggering with UV light. The volume change of these monodisperse nanoparticles comprising spiropyran, which undergoes reversible photoisomerization, and PEGylated lipid enables repetitive dosing from a single administration and enhances tissue penetration. The photoswitching allows particles to fluoresce and release drugs inside cells when illuminated with UV light. The mechanism of the light-induced size switching and triggered-release is studied. These particles provide spatiotemporal control of drug release and enhanced tissue penetration, useful properties in many disease states including cancer.

Via: 80Beats

Reference:

Rong Tong, Houman D. Hemmati, Robert Langer, and Daniel S. Kohane, (2012). Photoswitchable Nanoparticles for Triggered Tissue Penetration and Drug Delivery. Journal of the American Chemical Society, DOI: 10.1021/ja211888a

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