New gene test may help early lung cancer patients; Research

Lung CancerResearchers have developed a new test for the lung cancer that can detect which tumors can be more fatal.

This research has been done by the researchers from University of California, San Francisco (UCSF) and published online in the January 27 issue of the journal The Lancet.

Lung cancer is the most common cause of cancer death in the world.

Researchers have done two huge clinical trials on the molecular genetics of lung cancer including early-stage patients from Northern California Kaiser hospitals as well as from China. Researchers took tissue samples of 433 Northern California Kaiser patients and 1,006 patients from China.

In the trials, 14-gene test was done on patients and this test was able to determine correctly the patient’s odds of death within five years of surgery. In this test, biological makeup of the tumor was analyzed.

This molecular assay is originally made at UCSF but developed by a Mountain View Company’s Pinpoint Genomics. This assay analyzes the activity level of 14 genes in preserved tissue sample as compared to levels in the normal lung. It then specifies whether the tumor has a high, intermediate or low levels of risk of death.

This test could help patients in the decision to undergo or not further chemotherapy or targeted radiation.

Reference:

Johannes R Kratz MD, Prof Jianxing He MD, Stephen K Van Den Eeden PhD, Prof Zhi-Hua Zhu MD, Prof Wen Gao MD, Patrick T Pham BS, Michael S Mulvihill BS, Fatemeh Ziaei BS, Huanrong Zhang MD, Bo Su MD, Prof Xiuyi Zhi MD, Charles P Quesenberry PhD, Laurel A Habel BS, Qiuhua Deng BS, Zongfei Wang BS, Jiangfen Zhou BS, Huiling Li PhD, Mei-Chun Huang PhD, Che-Chung Yeh PhD, Prof Mark R Segal PhD, M Roshni Ray BS, Prof Kirk D Jones MD, Dan J Raz MD, Zhidong Xu MD, Thierry M Jahan MD, David Berryman PharmD, Biao He PhD, Dr Michael J Mann MD, Prof David M Jablons MD, (2012). A practical molecular assay to predict survival in resected non-squamous, non-small-cell lung cancer: development and international validation studies. The Lancet, doi:10.1016/S0140-6736(11)61941-7

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