Research suggestions for Nano-products in Cancer therapy

Carbon nanotubeNanoparticles’ (NPs’) use in therapeutic and diagnostic fields is emerging. However, according to the researchers, many of the questions related to the use of these nanoparticles are still unsolved “such as pharmacokinetics, biodistribution and side effects of the nanotherapy, and safety profile of NPs before and after conjugation and toxicity.” (João Conde et. al.)

 

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Like other nanoproducts, carbon nanotubes (CNTs) are also gaining potential in cancer therapeutic strategies. Researchers have found that CNTs are up-taken by cells but the mechanism of CNT penetration into cells is still not clear. It has been found that multi-walled carbon nanotubes (MWNT) smaller than 1 µm can be easily taken into the cells but the process is not essentially through endocytosis. (Abdelbary M. A. Elhissi et. al.)

As more and more knowledge has been gained, questions like “Are noble metal NPs cytotoxic or biocompatible? And how can the NPs be design to avoid these effects?” are attracting more and more researchers such as further widespread application of core/shell or alloy noble metal NPs allowing blend of the advantages of each noble metal into a single carrier has to be worked on. (João Conde et. al.)

Paclitaxel is an anticancer molecule, which is poorly water-soluble and Cremophor EL is used to solubilise the drug but Cremophor EL is toxic, so researching an appropriate alternative is very important. (Abdelbary M. A. Elhissi et. al.)

Reference:

João Conde, Gonҫalo Doria, and Pedro Baptista, (2012). Noble Metal Nanoparticles Applications in Cancer. Journal of Drug Delivery, doi:10.1155/2012/751075

Abdelbary M. A. Elhissi, Waqar Ahmed, Israr Ul Hassan, Vinod. R. Dhanak, and Antony D’Emanuele, (2012). Carbon Nanotubes in Cancer Therapy and Drug Delivery. Journal of Drug Delivery, doi:10.1155/2012/837327

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